BACKGROUND: AROMATIC CONDENSED OXAZINONE DERIVATIVES HAVE RECEIVED CONSIDERABLE ATTENTION DUE TO THE ATTRACTIVE PHARMACOLOGICAL PROPERTIES ASSOCIATED WITH THEIR HETEROCYCLIC SCAFFOLD [1]. NAPHTHOXAZINE, AN IMPORTANT MOTIF IN HETEROCYCLIC CHEMISTRY, HAS REPORTED CYTOTOXIC AND ANTIFUNGAL ACTIVITIES [2]. THEREFORE, DEVELOPMENT OF SIMPLE, ROBUST AND SAFER METHODOLOGIES FOR THE SYNTHESIS OF NAPHTHOXAZINONE DERIVATIVES IS OF PRIME INTEREST FOR OBTAINING THESE PRODUCTS UNDER CONDITIONS TOLERATED BY SENSITIVE FUNCTIONAL GROUPS FROM BOTH SYNTHETIC AND ENVIRONMENTAL POINTS OF VIEW. THE ROLE OF COPPER NANOPARTICLES IN COUPLING CHEMISTRY HAS BEEN WELL DOCUMENTED [3-4].METHODS: AN EFFICIENT PROTOCOL FOR THE SYNTHESIS OF 2-NAPHTHOL-CONDENSED 1, 3-OXAZINONE, (SCHEME1) BY THE REACTION BETWEEN BENZALDEHYDE, UREA, AND B-NAPHTHOL, WAS CARRIED OUT IN THE PRESENCE OF NA2CO3 AND COPPER FERRITE NANOPARTICLES STABILIZED BY PEG-400. THE PROGRESS OF THE REACTION WAS MONITORED BY TLC, AND THE PRODUCTS PURIFICATION THE CHARACTERIZED BY 1H NMR, 13C NMR, FT-IR AND MASS ANALYSIS.RESULTS: IN THE ABSENCE OF CU, THE REACTION WAS NOT INITIATED. WHEN THE SAME REACTION WAS CARRIED OUT WITHOUT PEG- 400, THE YIELD WAS ONLY 30%, THE IDEAL SOLVENT FOR THIS SYNTHESIS IS PEG-400. BECAUSE IT ACTS AS A SOLVENT AND CU NANOPARTICLES STABILAZER.CONCLUSION: THIS PROCESS IS SIMPLE, COST EFFECTIVE, GREEN AND ECO-FRIENDLY AS IT IS A ONE-POT SYNTHESIS WITH EASY WORKUP AND DOES NOT REQUIRE SPECIAL CONDITIONS SUCH AS ELEVATED TEMPERATURE AND HARSH REAGENTS, ALSO NEEDS LESSER QUANTITY OF CATALYST (USUALLY MG) AND THE COPPER-NANOPARTICLES CAN BE USED TO AN EFFICIENT RECYCLABLE MEDIUM.

PYRAZOLOPYRIDINES AND THEIR DERIVATIVES HAVE A WIDE RANGE OF BIOLOGICAL ACTIVITIES. THEY EXHIBIT IMPORTANT BIOLOGICAL PROPERTIES SUCH AS ANXIOLYTIC, ANTIALLERGIC AND ANTIHERPETIC PROPERTIES. THEREFORE, THE DEVELOPMENT OF SIMPLE METHODS FOR THE SYNTHESIS OF PYRAZOLOPYRIDINES IS AN IMPORTANT CHALLENGE. UNDOUBTEDLY, THE SYNTHESIS OF PYRAZOLOPYRIDINES THROUGH MULTICOMPONENT REACTIONS (MCR) HAS BEEN PAID MUCH ATTENTION OWING TO EXCELLENT SYNTHETIC EFFICIENCY, INHERENT ATOM ECONOMY, PROCEDURAL, SIMPLICITY, AND ENVIRONMENTAL FRIENDLINESS….

TRYPTANTHRIN IS A NATURAL PRODUCT, WHICH SHOWS SIGNIFICANT BIOLOGICAL ACTIVITY SUCH AS ANTIBACTERIAL [1], ANTIPARASITIC [2], AND ANTINEOPLASTIC [3] PROPERTIES. THE MOST COMMON APPROACH FOR THE SYNTHESIS OF THESE COMPOUNDS INVOLVES THE CONDENSATION OF ISATOIC ANHYDRIDE AND ISATIN TO GIVE TRYPTANTHRIN IN MODERATE TO HIGH YIELDS. ...

APPLICATION OF SOLVENT-FREE REACTIONS IN ORGANIC SYNTHESIS, PARTICULARLY THOSE BASED ON IMIDAZOLIUM CATIONS, HAS GAINED ATTENTION IN RECENT YEARS [1-3]. HEREIN, A NOVEL ACIDIC IONIC LIQUID BASED ON IMIDAZOLIUM CATION IS DESIGNED, SYNTHESIZED AND SUCCESSFULLY USED AS CATALYST FOR THE ONE-POT...

AN EFFICIENT, MILD, AND ENVIRONMENTAL FRIENDLY METHOD HAS BEEN DEVELOPED FOR THE SYNTHESIS OF DICOUMAROLS IN WATER OVER LEWIS ACID CATALYST BISMUTH VANADATE (BIVO4). THE METHOD INVOLVES THE CONDENSATION OF VARIOUS AROMATIC ALDEHYDES WITH 4HYDROXYCOUMARIN. ...

THE USE OF HETEROPOLYACIDS (HPAS) HAS RECENTLY RECEIVED CONSIDERABLE ATTENTION AS NONTOXIC, ECO-FRIENDLY AND ENVIRONMENTALLY BENIGN CATALYSTS FOR VARIOUS ORGANIC TRANSFORMATIONS TO AFFORD THE CORRESPONDING PRODUCTS IN GOOD YIELDS. [1, 2] HOWEVER, SYNTHESIS OF SIX-MEMBERED NITROGEN HETEROCYCLIC COMPOUNDS SUCH AS PIPERIDINES AND THEIR ANALOGUES IS VERY IMPORTANT BECAUSE OF THEIR BIOLOGICAL ACTIVITIES SUCH AS ANTIMALARIAL, ANTIHYPERTENSIVE, ANTIBACTERIAL, NEURO-PROTECTIVE, ANTICONVULSANT AND ANTI-INFLAMMATORY AGENTS [3, 4]. FURTHERMORE, GREEN SYNTHESIS OF THESE COMPOUNDS ARE VERY IMPORTANT AT THIS TIME. THEREFORE WE REPORT HEREIN AN EFFICIENT AND CONVENIENT PROCEDURE FOR THE GREEN SYNTHESIS OF HIGHLY SUBSTITUTED PIPERIDINES VIA ONE-POT THREE-COMPONENT REACTION BETWEEN AROMATIC ALDEHYDES, ANILINES AND B–KETOESTERS CATALYZED BY PREYSSLER TYPE HETROPOLYACID IN ETHANOL. (SCHEME 1)

COUMARIN AND SOME OF ITS HYDROXYLATED DERIVATIVES CONTAINING A BENZENE RING FUSED WITH AC-PYRONE RING POSSESS IMPORTANT CHEMICAL REACTIVITY AND ARE NATURALLY OCCURRING COMPOUNDS, WHICH EXHIBIT ANTIBACTERIAL, ANTIOXIDANT, ANTICANCER, AND ANTIALLERGY ACTIVITIES…..